diff --git a/core/simd/x86/sse42.odin b/core/simd/x86/sse42.odin
new file mode 100644
index 000000000..62b4f0478
--- /dev/null
+++ b/core/simd/x86/sse42.odin
@@ -0,0 +1,149 @@
+//+build i386, amd64
+package simd_x86
+
+import "core:simd"
+
+_SIDD_UBYTE_OPS                :: 0b0000_0000
+_SIDD_UWORD_OPS                :: 0b0000_0001
+_SIDD_SBYTE_OPS                :: 0b0000_0010
+_SIDD_SWORD_OPS                :: 0b0000_0011
+
+_SIDD_CMP_EQUAL_ANY            :: 0b0000_0000
+_SIDD_CMP_RANGES               :: 0b0000_0100
+_SIDD_CMP_EQUAL_EACH           :: 0b0000_1000
+_SIDD_CMP_EQUAL_ORDERED        :: 0b0000_1100
+
+_SIDD_POSITIVE_POLARITY        :: 0b0000_0000
+_SIDD_NEGATIVE_POLARITY        :: 0b0001_0000
+_SIDD_MASKED_POSITIVE_POLARITY :: 0b0010_0000
+_SIDD_MASKED_NEGATIVE_POLARITY :: 0b0011_0000
+
+_SIDD_LEAST_SIGNIFICANT        :: 0b0000_0000
+_SIDD_MOST_SIGNIFICANT         :: 0b0100_0000
+
+_SIDD_BIT_MASK                 :: 0b0000_0000
+_SIDD_UNIT_MASK                :: 0b0100_0000
+
+@(require_results, enable_target_feature="sse4.2")
+_mm_cmpistrm :: #force_inline proc "c" (a: __m128i, b: __m128i, $IMM8: i8) -> __m128i {
+	return transmute(__m128i)pcmpistrm128(transmute(i8x16)a, transmute(i8x16)b, IMM8)
+}
+@(require_results, enable_target_feature="sse4.2")
+_mm_cmpistri :: #force_inline proc "c" (a: __m128i, b: __m128i, $IMM8: i8) -> i32 {
+	return pcmpistri128(transmute(i8x16)a, transmute(i8x16)b, IMM8)
+}
+@(require_results, enable_target_feature="sse4.2")
+_mm_cmpistrz :: #force_inline proc "c" (a: __m128i, b: __m128i, $IMM8: i8) -> i32 {
+	return pcmpistriz128(transmute(i8x16)a, transmute(i8x16)b, IMM8)
+}
+@(require_results, enable_target_feature="sse4.2")
+_mm_cmpistrc :: #force_inline proc "c" (a: __m128i, b: __m128i, $IMM8: i8) -> i32 {
+	return pcmpistric128(transmute(i8x16)a, transmute(i8x16)b, IMM8)
+}
+@(require_results, enable_target_feature="sse4.2")
+_mm_cmpistrs :: #force_inline proc "c" (a: __m128i, b: __m128i, $IMM8: i8) -> i32 {
+	return pcmpistris128(transmute(i8x16)a, transmute(i8x16)b, IMM8)
+}
+@(require_results, enable_target_feature="sse4.2")
+_mm_cmpistro :: #force_inline proc "c" (a: __m128i, b: __m128i, $IMM8: i8) -> i32 {
+	return pcmpistrio128(transmute(i8x16)a, transmute(i8x16)b, IMM8)
+}
+@(require_results, enable_target_feature="sse4.2")
+_mm_cmpistra :: #force_inline proc "c" (a: __m128i, b: __m128i, $IMM8: i8) -> i32 {
+	return pcmpistria128(transmute(i8x16)a, transmute(i8x16)b, IMM8)
+}
+@(require_results, enable_target_feature="sse4.2")
+_mm_cmpestrm :: #force_inline proc "c" (a: __m128i, la: i32, b: __m128i, lb: i32, $IMM8: i8) -> __m128i {
+	return transmute(__m128i)pcmpestrm128(transmute(i8x16)a, la, transmute(i8x16)b, lb, IMM8)
+}
+@(require_results, enable_target_feature="sse4.2")
+_mm_cmpestri :: #force_inline proc "c" (a: __m128i, la: i32, b: __m128i, lb: i32, $IMM8: i8) -> i32 {
+	return pcmpestri128(transmute(i8x16)a, la, transmute(i8x16)b, lb, IMM8)
+}
+@(require_results, enable_target_feature="sse4.2")
+_mm_cmpestrz :: #force_inline proc "c" (a: __m128i, la: i32, b: __m128i, lb: i32, $IMM8: i8) -> i32 {
+	return pcmpestriz128(transmute(i8x16)a, la, transmute(i8x16)b, lb, IMM8)
+}
+@(require_results, enable_target_feature="sse4.2")
+_mm_cmpestrc :: #force_inline proc "c" (a: __m128i, la: i32, b: __m128i, lb: i32, $IMM8: i8) -> i32 {
+	return pcmpestric128(transmute(i8x16)a, la, transmute(i8x16)b, lb, IMM8)
+}
+@(require_results, enable_target_feature="sse4.2")
+_mm_cmpestrs :: #force_inline proc "c" (a: __m128i, la: i32, b: __m128i, lb: i32, $IMM8: i8) -> i32 {
+	return pcmpestris128(transmute(i8x16)a, la, transmute(i8x16)b, lb, IMM8)
+}
+@(require_results, enable_target_feature="sse4.2")
+_mm_cmpestro :: #force_inline proc "c" (a: __m128i, la: i32, b: __m128i, lb: i32, $IMM8: i8) -> i32 {
+	return pcmpestrio128(transmute(i8x16)a, la, transmute(i8x16)b, lb, IMM8)
+}
+@(require_results, enable_target_feature="sse4.2")
+_mm_cmpestra :: #force_inline proc "c" (a: __m128i, la: i32, b: __m128i, lb: i32, $IMM8: i8) -> i32 {
+	return pcmpestria128(transmute(i8x16)a, la, transmute(i8x16)b, lb, IMM8)
+}
+@(require_results, enable_target_feature="sse4.2")
+_mm_crc32_u8 :: #force_inline proc "c" (crc: u32, v: u8) -> u32 {
+	return crc32_32_8(crc, v)
+}
+@(require_results, enable_target_feature="sse4.2")
+_mm_crc32_u16 :: #force_inline proc "c" (crc: u32, v: u16) -> u32 {
+	return crc32_32_16(crc, v)
+}
+@(require_results, enable_target_feature="sse4.2")
+_mm_crc32_u32 :: #force_inline proc "c" (crc: u32, v: u32) -> u32 {
+	return crc32_32_32(crc, v)
+}
+@(require_results, enable_target_feature="sse4.2")
+_mm_cmpgt_epi64 :: #force_inline proc "c" (a: __m128i, b: __m128i) -> __m128i {
+	return transmute(__m128i)simd.lanes_gt(transmute(i64x2)a, transmute(i64x2)b)
+}
+
+when ODIN_ARCH == .amd64 {
+	@(require_results, enable_target_feature="sse4.2")
+	_mm_crc32_u64 :: #force_inline proc "c" (crc: u64, v: u64) -> u64 {
+		return crc32_64_64(crc, v)
+	}
+}
+
+@(private, default_calling_convention="c")
+foreign _ {
+	// SSE 4.2 string and text comparison ops
+	@(link_name="llvm.x86.sse42.pcmpestrm128")
+	pcmpestrm128 :: proc(a: i8x16, la: i32, b: i8x16, lb: i32, #const imm8: i8) -> u8x16 ---
+	@(link_name="llvm.x86.sse42.pcmpestri128")
+	pcmpestri128 :: proc(a: i8x16, la: i32, b: i8x16, lb: i32, #const imm8: i8) -> i32 ---
+	@(link_name="llvm.x86.sse42.pcmpestriz128")
+	pcmpestriz128 :: proc(a: i8x16, la: i32, b: i8x16, lb: i32, #const imm8: i8) -> i32 ---
+	@(link_name="llvm.x86.sse42.pcmpestric128")
+	pcmpestric128 :: proc(a: i8x16, la: i32, b: i8x16, lb: i32, #const imm8: i8) -> i32 ---
+	@(link_name="llvm.x86.sse42.pcmpestris128")
+	pcmpestris128 :: proc(a: i8x16, la: i32, b: i8x16, lb: i32, #const imm8: i8) -> i32 ---
+	@(link_name="llvm.x86.sse42.pcmpestrio128")
+	pcmpestrio128 :: proc(a: i8x16, la: i32, b: i8x16, lb: i32, #const imm8: i8) -> i32 ---
+	@(link_name="llvm.x86.sse42.pcmpestria128")
+	pcmpestria128 :: proc(a: i8x16, la: i32, b: i8x16, lb: i32, #const imm8: i8) -> i32 ---
+	@(link_name="llvm.x86.sse42.pcmpistrm128")
+	pcmpistrm128 :: proc(a, b: i8x16, #const imm8: i8) -> i8x16 ---
+	@(link_name="llvm.x86.sse42.pcmpistri128")
+	pcmpistri128 :: proc(a, b: i8x16, #const imm8: i8) -> i32 ---
+	@(link_name="llvm.x86.sse42.pcmpistriz128")
+	pcmpistriz128 :: proc(a, b: i8x16, #const imm8: i8) -> i32 ---
+	@(link_name="llvm.x86.sse42.pcmpistric128")
+	pcmpistric128 :: proc(a, b: i8x16, #const imm8: i8) -> i32 ---
+	@(link_name="llvm.x86.sse42.pcmpistris128")
+	pcmpistris128 :: proc(a, b: i8x16, #const imm8: i8) -> i32 ---
+	@(link_name="llvm.x86.sse42.pcmpistrio128")
+	pcmpistrio128 :: proc(a, b: i8x16, #const imm8: i8) -> i32 ---
+	@(link_name="llvm.x86.sse42.pcmpistria128")
+	pcmpistria128 :: proc(a, b: i8x16, #const imm8: i8) -> i32 ---
+	// SSE 4.2 CRC instructions
+	@(link_name="llvm.x86.sse42.crc32.32.8")
+	crc32_32_8 :: proc(crc: u32, v: u8) -> u32 ---
+	@(link_name="llvm.x86.sse42.crc32.32.16")
+	crc32_32_16 :: proc(crc: u32, v: u16) -> u32 ---
+	@(link_name="llvm.x86.sse42.crc32.32.32")
+	crc32_32_32 :: proc(crc: u32, v: u32) -> u32 ---
+
+	// AMD64 Only
+	@(link_name="llvm.x86.sse42.crc32.64.64")
+	crc32_64_64 :: proc(crc: u64, v: u64) -> u64 ---
+}